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A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. 2000;283(8):1038-1045Pub Med Article Molijn GJ, Koper JW, van Uffelen CJ, et al.

Temperature-induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leucocyte in patients with sepsis or septic shock. 1995;43(2):197-203Pub Med Article Keh D, Boehnke T, Weber-Cartens S, et al.

Sepsis is a clinical syndrome that occurs in patients with infection (known or suspected) defined by the presence of two or more systemic inflammatory response syndrome (SIRS) criteria, which include the following:92-94%.

[12] In their multi-centre, placebo-controlled, double-blind RCT, patients with evidence of at least two systemic inflammatory response syndrome (SIRS) criteria and evidence of organ dysfunction for less than 48 hours were randomised to receive either a continuous effusion of 200mg of hydrocortisone or placebo for 5 days. 6 days, p=0.35), as well as organ dysfunction (SOFA score 5 vs. Secondary infections, GI bleeds, weaning failure and other adverse events were not significant between the 2 groups, apart from significantly more episodes of hyperglycaemia in the hydrocortisone group (90.9% vs. This trial attempts to address a long-standing question which many intensivists continue to struggle with.Previous randomized controlled trials (RCTs) and meta-analyses evaluated the efficacy and safety of adjunctive corticosteroids for community-acquired pneumonia (CAP).However, the results from them had large discrepancies.OR for all-cause death: 0.80 (95% confidence interval (95% CI) 0.53–1.21) from all studies; 0.41 (95% CI 0.19–0.90) from severe-case subgroup; 0.21 (95% CI 0.0–0.74) from intensive care unit (ICU) subgroup.Length of ICU stay: −1.30 days (95% CI (−3.04)−0.44).

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